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Author

Junyan Wang

2 papers indexed here

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Open access Aug 2026

N-linked glycosylation of the EP3α receptor is essential for the regulation of platelet homeostasis

Platelet activation and aggregation represent pivotal events in hemostasis and thrombosis. Prostaglandin E2 (PGE 2 ) receptor subtype 3 (EP3), the most abundantly expressed PGE 2 receptor in platelets, regulates platelet activation. Yet, the underlying mechanisms remain incompletely defined. Glycosylation, one...

Yuhong Wang, Yizhe Li, Junyan Wang et al. · 0 citations
Open access Jul 2026

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

The DNA- encoded library screening-guided isolation and pharmacological characterization of the first small molecule AT1R allosteric ligands are reported, uncovering new mechanisms for precisely controlling the dynamic behavior of the AT1R with implications for drug development targeting this pathophysiologically impor...

Samuel Liu, Peng Xiao, M. Elgeti et al. · 0 citations

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