Author

Juwon Park

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Open access Aug 2026

Aberrant excitatory neuronal ERBB4 promotes Alzheimer’s disease pathology

Neuroinflammation and synapse loss are associated with cognitive decline in Alzheimer’s disease (AD). Although microglial hyperphagocytic activity has been implicated in synapse loss1, 2, 3–4, the mechanisms underlying these pathologies remain obscure. Here we demonstrate that, during AD progression in mice, astrocytes...

Seyoung Lee, Eunseok Park, Ha-Eun Lee et al. · Nature · 2 citations · ⚡1

Open access Aug 2026

Machine Learning-Driven Drug Repositioning Identifies Putative IRAK4 Inhibitors Through Structure-Based Computational Evaluation

Results demonstrate that approaches incorporating machine learning and structure-based computational analysis can be useful for discovering and prioritizing potential IRAK4 inhibitor candidates.

H. Na, Juwon Park, Jiwon Choi · Current Issues in Molecular... · 0 citations