K. A. Alzahrani

Integrated computational and experimental studies on benzothiazine–chalcone hybrids: Crystal Structures, in silico modeling, and in vitro evaluation of α-glucosidase inhibition and antioxidant activity

The pharmacophore fusion approach is a well-established strategy in drug discovery for designing new pharmacophores from the existing pharmacophores with potential biological applications. The 1,2-benzothiazine based ketone is condensed with halogenated aldehydes to isolate 1,2-benzothiazine hybrid chalcones. These c...