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Author

K. Ahmad

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Review Open access Sep 2026

Hypertranscription: the invisible hand in cancer epigenetics

Global upregulation of transcription, or hypertranscription, is observed in most human cancers, driven by the action of oncogene-encoded transcription factors (TFs). TF interactions with RNA Polymerase II (Pol II) are mediated by kinases that phosphorylate the Pol II C-terminal domain (CTD) to drive productive elonga...

S. Henikoff, Robert N. Eisenman, K. Ahmad · 0 citations
Open access Jul 2026

Aclarubicin disrupts RNA polymerase II progression at replication-coupled histone genes

Anthracyclines are highly effective chemotherapeutic agents that cause DNA and chromatin damage. One member of the anthracyclines, aclarubicin, has recently gained therapeutic interest due to its ability to kill cancer cells through chromatin-based mechanisms, thus avoiding the off-target effects associated with DNA da...

Kevin K. Nguyen, Matthew Wooten, K. Ahmad et al. · 0 citations

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