Open access
Jul 2026
Genetic dose-response modelling predicts drug mechanisms, dosing, and adverse events
Understanding how changes in gene function affect disease risk is central to drug development. Genetic variants are natural perturbations of gene activity and provide an opportunity to systematically model dose-response relationships between genes and phenotypes. Here, we present Variant-Informed Dose-Response Analysis...
L. Stefanucci, D. Considine, Z. Ke et al.
· medRxiv · 0 citations