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Aug 2026

T-cell immunosenescence limits CD19 CAR T-cell function in chronic lymphocytic leukemia.

Ibrutinib improved proliferative fitness, attenuated senescence-associated features and SASP output in paired patient and direct-exposure assays, and enhanced CAR T-cell expansion in an ibrutinib-resistant CLL model.

Julia Han Noll, Devin Dersh, Jiang-Yuan Li et al. · 0 citations
Open access Aug 2026

Mycodnaviridae is a clade of giant viruses that persistently infect zoosporic fungi

Both “viral fossils” and active infection by giant viruses in fungi, particularly in the zoosporic phyla Blastocladiomycota and Chytridiomycota are reported, suggesting that viral activation may be constrained to certain life stages of the host.

J. Myers, F. Schulz, S. Rahimlou et al. · 2 citations

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