K. Baek

Balancing Ubiquitination and Deubiquitination in Apoptotic Protein Stability and Cancer Cell Survival

Programmed cell death is essential for maintaining cellular homeostasis, and its evasion is a defining hallmark of cancer. The threshold for apoptosis is largely determined by the stability of pro- and anti-apoptotic proteins, which is tightly regulated by the ubiquitin–proteasome system (UPS). In this system, E1, E2,...