Author

Khaled H. Barakat

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Review Open access Oct 2026

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting.

SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA re...

Maryam Jama, M. Overduin, K. Barakat · Medicinal research reviews (... · 0 citations

Open access Aug 2026

Multi-Target Pharmacological Mechanisms of Cannabidiol in Breast, Colorectal, and Lung Cancer: An Integrated Network Pharmacology and Molecular Docking Study

Combining pooled cancer-associated network pharmacology with co-crystallized ligand benchmarking suggests that CBD may exert its biological activity through coordinated modulation of multiple cancer-related signaling pathways rather than a single molecular target.

Marlon C. Mallillin, A. Chattopadhyay, Irish Mhel C. Mitra et al. · Journal of Phytomedicine · 0 citations

Jul 2026

Abstract B055: A Genome-to-Vaccine: An Integrated Deep learning-Driven Neoantigen Identification and Multi-Epitope Vaccine Construction for Personalized Melanoma Immunotherapy

Overall, the results suggest that the proposed MEVC is stable and immunogenic; however, experimental and preclinical validation is required to confirm these findings.

S. Ismail, Devin Atkin, Khaled H. Barakat · Cancer Research · 0 citations