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K. Blyth

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Open access Oct 2026

Macrophage-induced ferritin expression protects pancreatic cancer cells from ferroptosis.

Reactive oxygen species (ROS) drive pro-tumorigenic signaling but also promote lipid peroxidation and ferroptosis, making ROS regulation critical during high oxidative stress stages of tumor progression, such as metastasis. Loss of the antioxidant TIGAR in pancreatic ductal adenocarcinoma (PDAC) cells raises ROS and en...

Eric C. Cheung, Meng-Han Wu, Wen-Chih Cheng et al. · 0 citations
Open access Sep 2026

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

Local and systemic effects of hepatocellular p53 activity and cholesterol during MASH development are investigated, suggesting that dietary cholesterol promotes detrimental overactivation of p53 in MASH and facilitates fibrosis within the liver and distal organs.

Celine I. Wittke, Dale M. Watt, L. Butler et al. · 0 citations

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