Unraveling the conundrum of multifaceted Pyruvate Kinase M2 in cancer: a potential therapeutic target with challenges in precision intervention.
Pyruvate kinase M2 (PKM2), a key glycolytic enzyme, plays a pivotal role in cancer-associated metabolic reprogramming and is frequently over-expressed in several malignancies. Beyond its metabolic activities, PKM2 exhibits numerous non-metabolic functions, mediated through a complex interplay of allosteric regulation,...