BACKGROUND: Subjective cognitive decline (SCD) may precede mild cognitive impairment (MCI), but not all individuals with SCD progress to MCI. Identifying which individuals are most likely to convert and over what time frame remains an important goal in Alzheimer's disease research. MRI measures of white matter hyperint...
F. Kamal, A. Metz, K. Chadwick et al.· medRxiv· 0 citations
Introduction: Cerebral small vessel disease (CSVD) lesions, including white matter hyperintensities (WMHs), lacunar infarcts, cerebral microbleeds (CMBs), and enlarged perivascular spaces (PVSs) are associated with increased risk of dementia. In this study, we aimed to examine their associations with risk factors, neur...
Z. Chen, S. Raeesi, A. Metz et al.· medRxiv· 0 citations
These findings, replicated in four diverse and independent datasets, support imaging-based subtyping as a scalable and clinically translatable approach for capturing heterogeneity in AD pathophysiology and associated cognitive trajectories.
A. Metz, Cassandra Polizzi, R. Moqadam et al.· medRxiv· 0 citations
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