Author

K. Chao

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Open access Sep 2026

Effectiveness of anti-TNF therapy after prior ustekinumab exposure in Crohn’s disease: A propensity-weighted cohort study

As ustekinumab is increasingly used earlier in Crohn’s disease (CD), evidence regarding the effectiveness of subsequent anti-tumor necrosis factor (TNF) therapy remains limited. We compared anti-TNF outcomes after prior ustekinumab exposure with first-line anti-TNF therapy in biologic-naïve patients. We co...

Jia-Wei Zhan, Wei-Yan Feng, Na Diao et al. · BMC Gastroenterology · 0 citations

Open access Sep 2026

Intestinal Ultrasound Predicts Primary Non-Response and Maintenance Relapse in Upadacitinib-Treated Active Crohn's Disease: A Multicenter, Prospective Cohort Study.

BACKGROUND Intestinal ultrasound (IUS) is increasingly used to monitor activity and predict treatment outcomes in Crohn's disease (CD), but its role in predicting primary non-response (PNR) to Upadacitinib (UPA) and identifying maintenance relapse remains unclear. METHODS In this multicenter prospective cohort study,...

Ren-Bin He, Yuan-Yuan Huang, Jing Han et al. · Alimentary Pharmacology and... · 0 citations

Open access Sep 2026

HMGCS2-mediated ketogenesis maintains intestinal barrier in inflammatory bowel disease by inhibiting ferroptosis

Complete mucosal healing is a key therapeutic goal in inflammatory bowel disease (IBD). While ferroptosis-mediated epithelial cell death is known to compromise the mucosal barrier as the cornerstone of mucosal healing, the precise mechanisms driving this process during IBD pathogenesis remain to be fully elucidated...

Jing Han, Xiao-Ling Li, Ying Wang et al. · Cell Death & Disease · 0 citations