Introduction The assessment of early ethological markers of neurodegeneration in Alzheimer’s disease (AD) remains a pivotal task in preclinical research. This study evaluates the diagnostic potential of the “Destruction-Building Test” (DBT), a novel assay based on the innate manipulative behaviors of rodents–specifical...
E. Ahremenko, A. Andreev, K. Chaprov et al.· Frontiers in Behavioral Neur...· 0 citations
Proteins α-, β-, and γ-synuclein in brain distributed predominantly in presynaptic terminals suggesting their role in regulating neurotransmitter release and signal transduction. Misfolded α-synuclein is involved in the pathology of Parkinson's disease which is characterized by the loss of dopaminergic neurons and the...
A. Fedulina, A. Baev, Alexey V. Emelyanov et al.· Neurochemistry International· 0 citations
Family proteins - α-, β, γ-synucleins shown to play important roles in metabolism, signal transduction and dopamine handling. Aggregated α-synuclein is neurotoxic and involved in pathogenesis of Parkinson's disease. The mechanism toxicity of aggregated α-synuclein includes lipid peroxidation, oxidative stress and ferro...
A. Fedulina, E. Seryogina, K. Chaprov et al.· Biochemical and Biophysical...· 1 citation
Chronic administration of low doses of DHQ exerted neuroprotective effects in both AD and ALS genetic models, which partially translated to reduced manifestations of these diseases.
E. Lysikova, K. Sitdikova, Aigerim Makhambetova et al.· Cells· 1 citation
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