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K. Chaprov

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Open access Aug 2026

Impaired behavioral flexibility and coping strategy shifts in 5xFAD mice in the novel Destruction-Building Test

Introduction The assessment of early ethological markers of neurodegeneration in Alzheimer’s disease (AD) remains a pivotal task in preclinical research. This study evaluates the diagnostic potential of the “Destruction-Building Test” (DBT), a novel assay based on the innate manipulative behaviors of rodents–specifical...

E. Ahremenko, A. Andreev, K. Chaprov et al. · 0 citations
Open access Oct 2026

Synucleins deficiency alter dopamine- and glutamate-induced calcium signal in neurons and astrocytes.

Proteins α-, β-, and γ-synuclein in brain distributed predominantly in presynaptic terminals suggesting their role in regulating neurotransmitter release and signal transduction. Misfolded α-synuclein is involved in the pathology of Parkinson's disease which is characterized by the loss of dopaminergic neurons and the...

A. Fedulina, A. Baev, Alexey V. Emelyanov et al. · 0 citations
Open access Aug 2026

Lack of synucleins induces an alteration of lipid peroxidation in the brain.

Family proteins - α-, β, γ-synucleins shown to play important roles in metabolism, signal transduction and dopamine handling. Aggregated α-synuclein is neurotoxic and involved in pathogenesis of Parkinson's disease. The mechanism toxicity of aggregated α-synuclein includes lipid peroxidation, oxidative stress and ferro...

A. Fedulina, E. Seryogina, K. Chaprov et al. · 1 citation

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