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Through modulation of the PP2A enzyme complex, mirtron-5010 also dampens IL-2—driven T-cell activation and proliferation, suggesting a role in shaping the tumor immune microenvironment.
Mirtrons, a specialized subclass of intron-derived microRNAs (miRNAs), bypass canonical Drosha-dependent processing by undergoing splicing and debranching to form pre-miRNA hairpins directly processed by Dicer. This alternative pathway imparts high structural stability and resistance to exonucleolytic degradation...
Immunofluorescence imaging demonstrated that mirtrons carried by tumor-derived exosomes are taken up by human monocyte U937 cells and are predominantly localized to the cytoplasm, consistent with the behavior of conventional miRNAs.
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