Open access
Sep 2026
Myeloperoxidase and anti-MPO IgG synergistically enhance TLR9-mediated immune activation in ANCA-associated vasculitis.
Anti-neutrophil cytoplasmic antibodies (ANCAs) target antigens in neutrophil granules, such as myeloperoxidase (MPO) or proteinase 3, causing small-vessel inflammation. ANCA pathogenicity is typically attributed to direct neutrophil activation, but a comprehensive understanding of its mode of action is lacking. In this...
Calvin Krollmann, Maria L. Saenz, Ruth-Miriam Koerber et al.
· Cell Reports · 0 citations