Author

K. D. Sørensen

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Open access Sep 2026

Integrated signatures define mutational processes in prostate cancer.

Prostate cancer follows a long and heterogeneous disease course with incompletely understood aetiology1. Here we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group and assess their clinical relevance. By integrating de novo extracted single-base substitution, insertion...

A. Gruber, A. Olsen, Bárbara Hernando et al. · Nature · 1 citation

Open access Sep 2026

High-definition spatial transcriptomics visualizes the cellular and molecular architecture underlying perineural invasion in localized prostate cancer

Distinguishing indolent from aggressive tumors remains a key challenge in the clinical management of prostate cancer (PC), highlighting the need for better tools for accurate risk stratification. A defining feature of aggressive PC is its propensity for perineural invasion (PNI), a pathological finding that is associat...

P. V. Salachan, L. Raaby, Jacob Fredsøe et al. · Journal of Hematology & Onco... · 0 citations