K. Deisseroth

Neocortical long-range inhibition promotes cortical synchrony and sleep

Sleep and wakefulness are associated with distinct cortical patterns of rhythmic activity1. During low-arousal states such as slow-wave sleep, synchronous low-frequency rhythms dominate activity across widespread cortical regions. Although inhibitory neurons are increasingly recognized as key regulators of cortical sta...

Hippocampo-septal inhibitory feedback controls the medial septal circuit as a function of brain state, pyramidal cell activity and movement speed

Diffusion MRI Tractography Predicts Electrophysiological Connectivity and Explains Spectral Signatures of Evoked Potentials in the Human Brain

Coevolutionary mining of prokaryotic non-coding elements with a genome language model

Microbial genomes encode non-coding RNAs (ncRNAs) and nucleic-acid-interacting proteins essential to biology and biotechnology. However, discovery of these systems remains protein-centric and based on similarity to known sequences. Here, we introduce Minerva, a framework for coevolutionary mining that uses genome langu...

Developmental xenocortication using human-derived organoids in mice

This platform establishes a transplantation platform using a genetic strategy to effectively deplete glutamatergic neurons from mouse neocortex and hippocampus and neonatally engraft the cortical cavity with human stem-cell-derived cortical organoids (hCO) to generate xenocortical mice, and envision that xenocorticatio...

AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo

This work developed genetically-encoded lysosome targeting chimeras (GELYTACs) that target circulating IgGs for clearance and degradation and establishes GELYTACs as a possible therapeutic modality that is deliverable using genetic medicine approaches.