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Open access Aug 2026

mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia.

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by impaired B-cell maturation and poor prognosis in relapsed/refractory (R/R) cases. While CD20-targeted immunotherapies offer clinical benefit, their efficacy is limited by low and heterogeneous CD20 expression on BCP-ALL cells. In this study, we...

Agnieszka Dąbkowska, Martyna Janowska, Agata Pastorczak et al. · 0 citations
Open access Aug 2026

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy.

CD19-CAR-T cells are a major therapy for relapsed/refractory B-cell malignancies, yet ~50% of patients relapse after infusion. Clinical data suggest that tisa-cel treatment is associated with higher rates of CD19 mutation than axi-cel, though direct comparisons have been lacking. Although both products target the FMC63...

Marta Krawczyk, K. Fidyt, Narcís Fernandez-Fuentes et al. · 0 citations

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