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Author

K. Homma

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Open access Aug 2026

Honokiol-mediated reversal of cisplatin-induced transcriptomic changes in outer hair cells.

Cisplatin-induced hearing loss (CIHL) affects half a million cancer patients annually, but treatment strategies are limited. We have previously shown that honokiol, an antioxidant and otoprotective compound, upregulates mitochondrial sirtuin 3 (SIRT3) and protects against CIHL. In the present study, we investigated the...

Chail Koo, Robert J Fuentes, Prerita Pandya et al. · 0 citations
Open access Jul 2026

Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochlea

It is demonstrated that the short Slc26a4 isoform is expressed in both the inner ear and kidney and investigated its interactions and functions, and the genotype-phenotype association for SLC26A4-related hearing loss is characterized in the context of these two isoforms.

J. Koh, C. Affortit, K. Homma et al. · 0 citations

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