Open access
Oct 2026
APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction
Vascular-associated fibroblasts are a major source of pathogenic APOE4 that drives vascular dysfunction in cerebral amyloid angiopathy and are establish VAF-derived APOE4 as a compartment-specific driver of CAA and cerebrovascular dysfunction.
Fareeha Saadi, Yoonho Cho, Ilia V. Katritch et al.
· bioRxiv · 0 citations