172. Cerebrospinal fluid p75 neurotrophin receptor ectodomain differs between Alzheimer’s disease and late-life depression: links to cognition, sleep, and anxiety
Abstract Background Differentiating late-life depression (LLD) from prodromal or early Alzheimer’s disease (AD) is clinically difficult because affective and cognitive symptoms overlap and a subset of LLD patients shows amyloid-β (Aβ) positivity, limiting the specificity of core CSF Aβ/tau biomarkers. The p75 neurotrop...