Quality by Design-Based Optimization of Silymarin–Pioglitazone Nanoemulsion for Enhanced Topical Delivery
The primary objective of the present study was to develop and optimize a nanoemulsion formulation of silymarin and pioglitazone for enhanced topical delivery of antidiabetic effect using Quality by Design (QbD) approach. Both drugs exhibited poor aqueous solubility and low bioavailability in water and also had low bioa...