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Author

K. Kabashima

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Review Open access Aug 2026

A comprehensive atlas of somatic mutation rates and mutational signatures in normal human cells

Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune system to cancer. To inform understanding of somatic evolution in the human body we report the mutation rates and mutational...

M. H. Pham, L. M. R. Harvey, Thomas R. W. Oliver et al. · 0 citations
Review Jul 2026

Cytotoxic CD4+ T cells across aging: a conceptual framework for health, protection, pathology, and age-associated diseases.

A conceptual framework that places age-associated CD4 CTL expansion at the intersection of aging and age-associated disease is proposed, suggesting that at least a subset may be partially interconnected by recurrent CD4 CTL programs, while emphasizing that the strength of evidence and the degree of causality differ sub...

Tatsuya Hasegawa, Kosei Nishitani, K. Kabashima · 0 citations

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