Cellular senescence is a central hallmark of aging, yet its measurement in humans remains invasive, low-throughput and tissue-specific, precluding population-scale study. We developed Methylation-associated Gene Expression (MaGE) predictors: whole-blood DNA methylation proxies of p14ARF, p16INK4A and p21CIP1 expression...
Daniel J. Simpson, S. Crofts, Christos Mavrommatis et al.· medRxiv· 0 citations
A machine learning model using FDG-PET imaging to accurately predict Alzheimer’s-type tau pathology across spectrums of aging and dementia is developed, providing a novel framework to estimate tau burden non-invasively.
Nick Corriveau-Lecavalier, Ge-Meng Zhang, H. Botha et al.· Nature Communications· 0 citations
Introduction: Frontotemporal lobar degeneration (FTLD) is a devastating disease that commonly results in early onset dementia, yet its rarity and heterogeneity limit large-scale research and clinical trials. Remote monitoring via low-burden digital health tools may overcome these barriers. We evaluated clinical utility...
E. Paolillo, Sreya Dhanam, J. Taylor et al.· medRxiv· 0 citations
Findings lend support for PVS-BG as an early indicator of small vessel dysfunction and WMH pathogenesis and suggest that PVS-BG may identify individuals at increased risk of progressive SVD.
Audrey Low, J. Gunter, Ming-Zhao Hu et al.· Annals of Neurology· 0 citations
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