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Author

K. Kelleher

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Open access Oct 2026

SCOPE-based target and pathway enrichment identifies the histamine H1 receptor as a regulator of exodosis

Phenotypic screening enables discovery of small molecules without requiring predefined targets, but mechanistic interpretation remains challenging due to polypharmacology and pathway complexity. We developed SCOPE (Screening Compound Ontology for Pathway Enrichment), a KNIME-based computational framework tha...

Abhijeet Kapoor, K. Kelleher, S. Underhill et al. · 0 citations

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