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Author

K. Kubara

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Open access Oct 2026

Chemical Biology‐Based Drug Discovery Workflow Highlights Target Identification as a Key Step in Developing a Novel, Potent, and Selective GLUT1 Inhibitor

Discovery of bioactive compounds with novel chemical scaffolds remains a cornerstone of drug discovery. We designed a spiro scaffold composed of a cyclic imide and a diazepane to construct a focused compound library with minimal diversity. Screening for HCT‐116 cell growth inhibition, supported by growth curve analysis...

H. Kamiyama, Y. Onizawa, K. Kubara et al. · 0 citations

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