Response to Electroconvulsive Therapy in a Patient With SCN2A-Variant Catatonia Is Associated With Postictal Spreading Depolarization.
An 18-year-old female patient with a history of autism spectrum disorder and SCN2A loss-of-function variant received a course of electroconvulsive therapy (ECT) for catatonia, which had been present and disabling for 1 year. After a partial lorazepam taper, bitemporal ECT was initiated. The patient had a rapid and robu...