Optimized Lamotrigine-Loaded Polymeric Nanoparticles for Enhanced Drug Delivery: A Box-Behnken Design Approach with Integrated In Vivo Evaluation
The clinical utility of lamotrigine in epilepsy is limited by poor aqueous solubility, variable oral absorption, short half-life, and P-glycoprotein-mediated efflux at the blood-brain barrier. This study aimed to develop an optimized chitosan-sodium alginate polymeric nanoparticle system for Lamotrigine with desire...