K. Martinowich

Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability

Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease

It is demonstrated that pTau triggers phenotypes reflective of LC-NE hyperactivity in the early stages of AD pathogenesis, laying the foundation for the development of LC-based disease-modifying therapies to address neuropsychiatric manifestations.

Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

A spatial transcriptomic atlas of the human amygdala from nine neurotypical donors provides a foundational resource and framework for accelerating cross-species comparisons and human disease-focused investigations.