Author

K. Matsuoka

View on Semantic Scholar

2 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Sep 2026

Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (18F) Positron Emission Tomography.

BACKGROUND Florzolotau (18F) positron emission tomography (florzolotau PET) enables high-contrast in vivo detection of four-repeat tau pathology in progressive supranuclear palsy (PSP), but whether longitudinal tau imaging reflects disease progression remains unclear. OBJECTIVES To explore longitudinal tau accumulation using florzolotau PET and evaluate its association with clinical progression in PSP. METHODS Twenty-six patients with PSP (18 Richardson's syndrome [PSP-RS], 8 non-RS) and 10 age- and sex-matched healthy controls (HCs) underwent florzolotau PET, magnetic resonance imaging, and clinical assessments at baseline and after 1 year. Regional standardized uptake value ratios (SUVRs) were extracted across 57 regions of interest. Partial least squares (PLS) multivariate analyses revealed regions with elevated baseline SUVR and longitudinal increase (ΔSUVR) in PSP relative to HCs, alongside regions where ΔSUVR was associated with changes in PSP Rating Scale scores. RESULTS At baseline, tau deposition was most prominent in the globus pallidus (GP) and midbrain in patients with PSP. Longitudinal tau increases were observed in the GP, frontoparietal cortex, and cerebellar white matter, and minimal progression was observed in the midbrain. GP tau accumulation exhibited the strongest association with clinical progression in the PLS model among PSP-RS and a univariate correlation (Spearman's ρ = 0.688, P = 0.002). CONCLUSIONS This study provides in vivo evidence of the spatiotemporal progression of tau pathology in PSP. In the GP, tau accumulation emerges early and continues to increase with clinical deterioration. These findings support the utility of florzolotau PET for monitoring disease progression and as a biological outcome measure in tau-targeted therapeutic trials. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Yoshikazu Chishiki, Kenji Tagai, Y. Kataoka et al. · Movement Disorders · 0 citations

Open access Jul 2026

Linking auditory brain responses to cortical microstructure and sensory behaviors in autism spectrum disorder: a preliminary study

Introduction Atypical auditory processing is a core characteristic of autism spectrum disorder (ASD), potentially stemming from disrupted thalamocortical circuits and frontal modulation. This study investigated whether individual differences in cortical microstructure, as measured by neurite orientation dispersion and density imaging, are associated with auditory brainstem responses (ABR) and whether these ABR measures are associated with autism traits and atypical sensory processing. Methods We recruited 15 adults with ASD (9 males, 6 females; mean age 26.9 ± 6.7 years) and 12 typically developing controls (12 males; mean age 37.1 ± 8.0 years) and assessed microstructural properties in the thalamus, temporal cortex, and orbitofrontal cortex (OFC). Auditory processing was evaluated via ABR recorded under forward-masking conditions. Results In this preliminary, exploratory analysis, mediation models suggested that the amplitude of wave PVII mediated the association between the orientation dispersion index in the temporal cortex and autism traits, as measured by the Autism-Spectrum Quotient. Similarly, the ΔVI amplitude (peak-to-peak potential between NVI and PVI) mediated the relationship between the neurite density index in the OFC and atypical sensory behaviors, assessed using the Adolescent/Adult Sensory Profile. In the ASD group, reduced PVII amplitude was linked to difficulties in attention switching and imagination, while increased ΔVI amplitude was associated with sensory avoidance. Discussion/conclusion Our preliminary and exploratory findings tentatively suggest that microstructural variability in the temporal cortex and OFC may relate to auditory neural responses and to sensory and cognitive features of ASD. However, given the small and demographically imbalanced sample, these results should be regarded as hypothesis-generating rather than confirmatory. These candidate brain–behavior pathways should be tested in larger, demographically matched cohorts before any mechanistic interpretation regarding sensory dysfunction in autism can be drawn.

N. Kashida, Kazuhiko Yamamuro, K. Matsuoka et al. · Frontiers in Psychiatry · 0 citations