K. Ngiam

Prevalence of pharmacogenomically implicated prescriptions in multi-ethnic populations in Singapore.

AIM To assess the potential impact of implementing pre-emptive pharmacogenomic (PGx) testing in Singapore, focusing on prevalence and genetic actionability of PGx prescriptions. METHODS Electronic Health Records from 2014 to 2021 were obtained from the National University Hospital (NUH), a tertiary medical centre ser...

Development and Validation of an Interpretable Machine Learning Model for Inpatient Fall Risk Using Electronic Health Record Data

Background: Falls are the most common hospital-acquired adverse event, leading to extended hospitalization, loss of independence, disability, and premature death. Routine fall risk assessments are time-consuming, even with limited factors. An AI-derived fall prediction model can provide more comprehensive and comparabl...

From Guardrails to Compilers: A Constraint-First Runtime Substrate for Clinical AI Agents

PARTIAL ALTERNATIVE SPLICING IN CARRIERS OF DPYD rs75017182 EXPLAINS A MODEST ASSOCIATION WITH SEVERE

It is demonstrated that rs75017182‐ C promotes alternative splicing in the minigene plasmid model, and that the level of splicing may be affected by additional variants in linkage disequilibrium with rs75017182.