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Author

K. O'Connell

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Open access Sep 2026

Early-childhood temperament trajectories map onto transdiagnostic psychiatric risk.

Early-childhood temperament is associated with later mental health. Temperament continues to develop throughout the first years of life, and a single assessment cannot capture its trajectory. Whether departures from an individual's developmental trajectory carry psychiatric risk remains unknown. Using data from more th...

J. Kopal, N. Bakken, P. Parekh et al. · 0 citations
Open access Sep 2026

712. Comorbid mental and substance use disorders – the role of genetic susceptibility

It is demonstrated that the relationship between alcohol use and psychiatric disorders is driven by a complex, shared genetic architecture rather than environmental complications alone and underscores the value of multi-ancestry and cross-disorder genetic studies in SUD.

O. Andreassen, R. Icick, E. Wistrom et al. · 0 citations
Open access Sep 2026

Molecular Underpinnings of Retinal Traits 1 Shared with Major Psychiatric Disorders

Recent large-scale studies have enabled new knowledge about genetic underpinnings of morphological and electrophysiological alterations of the retina. Variation in retinal traits, often of neurodevelopmental origin, have been linked to major psychiatric disorders (MPDs). Here, we investigate the genetic overlap between...

P. Jahołkowski, N. Parker, I. Sveen et al. · 0 citations
Open access Aug 2026

Genetic liability to addiction underlies comorbid bipolar and substance use disorders.

By dissecting the genetic liability to SUD and SU and investigating their relationship with BIP, this work finds a genetic signature correlated with substance dependence but not substance use more broadly.

L. Ystaas, P. Parekh, N. Parker et al. · 0 citations
Aug 2026

Distinguishing different psychiatric disorders using DDx-PRS

Despite great progress on case–control polygenic prediction, an unmet need remains for a method that genetically distinguishes clinically related disorders (e.g., schizophrenia (SCZ) versus bipolar disorder (BIP) versus major depressive disorder (MDD) versus controls). We introduce differential diagnosis–polygenic risk...

W. Peyrot, G. Panagiotaropoulou, L. O. Olde Loohuis et al. · 0 citations

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