Effect of Single-Stranded DNA on the Lower Critical Solution Temperature of Poly(N-isopropylacrylamide): Implications for Thermoresponsive Polymer-Nucleic Acid Systems.
Poly(N-isopropylacrylamide) (PNIPAM) exhibits a coil-to-globule transition at its lower critical solution temperature (LCST), which is sensitive to cosolutes in aqueous solution. Although ions, alcohols, and urea have been extensively characterized, the effect of nucleic acids remains largely unexplored. This study sys...