Author

K. P. Leong

2 papers indexed here

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Open access Aug 2026

Cost-Effectiveness of Polygenic Risk Score-Guided Statin Therapy for Cardiovascular Disease Prevention in Singapore.

BACKGROUND Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality in Singapore. Under current guidelines, individuals at intermediate risk often do not receive preventive statin therapy despite potentially elevated genetic risk. Polygenic risk scores (PRSs) offer an opportunity to...

Irene Li Peng Ooi, Aloysius Wei-Yan Chia, Ying-Jie Chee et al. · JACC: Asia · 1 citation

PARTIAL ALTERNATIVE SPLICING IN CARRIERS OF DPYD rs75017182 EXPLAINS A MODEST ASSOCIATION WITH SEVERE

It is demonstrated that rs75017182‐ C promotes alternative splicing in the minigene plasmid model, and that the level of splicing may be affected by additional variants in linkage disequilibrium with rs75017182.

L. Hahn, Brianna M. Bembenek, Kelly J. Bouchonville et al. · 0 citations