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Open access Oct 2026

A Gap-Free Telomere-to-Telomere Genome Assembly of Talaromyces marneffei Strain B33c Provides Insights into Chromosomal Architecture and Comparative Genomics

Talaromyces marneffei is a thermally dimorphic fungal pathogen endemic to Southeast Asia and southern China, yet chromosome-scale genomic resources from early clinical isolates remain limited. Here, we combined PacBio HiFi sequencing with Oxford Nanopore and Hi-C validation to generate a gap-free, telomere-to-telomere...

Xin-Yu Zhou, Yan-Qing Zheng, Zhi-Wen Jiang et al. · 0 citations
Open access Sep 2026

Comparative transcriptome and proteome analysis of resistant and susceptible Talaromyces marneffei clinical isolates reveals a systemic multitiered defense network against azoles

A hierarchical azole-resistance model in T. marneffei is refined and a focused candidate panel for future mechanistic validation is provided to provide a focused candidate panel for future mechanistic validation.

Yan-Qing Zheng, Gao-Yuan Peng, Xiao-Feng Pang et al. · 0 citations

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