Author

K. Panageas

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Open access Sep 2026

Comprehensive analysis of germline pathogenic variants across melanoma

Although a heritable component is implicated in ~10% of melanomas, the prevalence and functional relevance of germline pathogenic variants (gPVs) in unselected patients remains unknown. We evaluated 701 patients with melanoma who underwent tumor-normal MSK-IMPACT sequencing (2015–2023) and germline analysis of ≥76 ca...

S. Lochrin, H. Walch, Y. Kemel et al. · npj Genomic Medicine · 0 citations

Aug 2026

Rule-Based Identification of a Reliable Real-World Cancer Recurrence Endpoint.

This scalable method enables derivation of real-world endpoints from EHR-based data and may be used to characterize outcomes for patients treated outside of prospective clinical trials and may inform the creation of synthetic control cohorts to support regulatory approvals for new drugs in rare tumor or biomarker defin...

J. Lavery, Samantha Brown, Chelsea Nichols et al. · Cancer Epidemiology, Biomark... · 0 citations