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Review Open access Oct 2026

Recombinant AAV Production Platforms: Comparative insights for gene therapy manufacturing

Recombinant adeno-associated virus (rAAV) has emerged as a leading platform for gene therapy, leveraging both naturally occurring and engineered capsids to deliver therapeutic transgenes. As clinical and research demand for rAAV has grown, vector quality and manufacturing consistency have become critical considerations...

Sylvain Cecchini, K. Parsi, Robert M. Kotin · 0 citations
Open access Sep 2026

Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation

The results define a stepwise framework for nuclear reorganization during human embryonic stem cell differentiation and reveal that the transition from pluripotency to a differentiated state proceeds through coordinated, temporally ordered structural events.

Xiangru Huo, D. Lafontaine, Thomas Reimonn et al. · 0 citations

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