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Open access Sep 2026

Antagonism of stress granules is key to SARS-CoV-2 infection and pathogenesis

ABSTRACT Viruses must subvert host responses to facilitate successful infection. While most antiviral responses are associated with interferons, stress granules (SGs) are another barrier to viral infection by inducing translation arrest. To combat SG activity, viruses have evolved mechanisms to disrupt formation and di...

R. E. Alvarado, Jennifer Chen, Kumari G. Lokugamage et al. · 0 citations
Open access Sep 2026

Clinical and Genomic Characterization of Chikungunya Virus Variant reveals a Novel nsP3 H377P Substitution during the 2015 Outbreak in Central Valley of Chiapas, Mexico.

OBJECTIVES To characterize the clinical, diagnostic and genomic features of chikungunya virus (CHIKV) infection among patients presenting with an acute dengue-like illness in the inland Central Valley of Chiapas, Mexico, during the 2015 outbreak. METHODS We retrospectively tested sera from 80 suspected cases using qR...

A. L. Gonzalez-Perez, Ana Vázquez, F. de Ory et al. · 0 citations
Open access Jul 2026

Molecular basis for chikungunya virus recognition of a mosquito-specific receptor

High-resolution cryo-electron microscopy structures of alphaviruses bound to Aedes albopictus Lachesin define distinct determinants of receptor binding in mosquitoes and humans for arthritogenic alphaviruses, with implications for countermeasure development and outbreak preparedness.

Xiao-Yi Fan, Wan-Yu Li, Jesse S. Plung et al. · 0 citations

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