INTRODUCTION
Because of the elevated prevalence and death rates of cancers such as breast, lung, colorectal, bladder, gastrointestinal, and liver malignancies, cancer remains an important global health issue. More productive, targeted, and personalized therapeutic treatments are crucial, as evidenced by the growing loa...
Hardha Balachandran, Gowramma Byran, S. Murugesan et al.· Current Cancer Drug Targets· 0 citations
Plant sterols are naturally occurring bioactive compounds widely recognized for their cholesterol-lowering effects. This narrative review critically evaluates current evidence regarding the role of phytosterols in insulin resistance, glucose metabolism, and type 2 diabetes mellitus (T2DM). Literature was collected from...
P. Deb Roy, V. Ramachandran, T. M et al.· Hacettepe university journal...· 0 citations
Multi-target inhibition of α-amylase, α-glucosidase, and human aldose reductase can significantly address postprandial hyperglycemia and subsequent diabetic complications, yet bovine colostrum peptides remain largely unscreened against these enzymes. Using a peptidomics-guided, integrated in silico and in vitro approac...
Shashank M. Patil, R. Ramu, K. Rajagopal et al.· Food Chemistry: X· 0 citations
Lung and breast cancers are among the major causes of cancer-related morbidity and mortality worldwide. Both these cancers share several dysregulated molecular processes, including common oncogenic signaling pathways and molecular targets. Therefore, the current study focuses on the dual anticancer potential of Annona...
S. Patil, Abhijit Das, K. Asgaonkar et al.· Computers in Biology and Med...· 0 citations
INTRODUCTION
Sida cordifolia (SC) is traditionally used for treat inflammatory disorders; however, its molecular composition and the mechanistic basis of action remain poorly characterized. This study aimed to identify its bioactive constituents and elucidate their multi-target anti-inflammatory potential using an inte...
K. Asgaonkar, A. Avalaskar, K. Rajagopal et al.· Current Computer - Aided Dru...· 0 citations
The docking, ADMET, and MD simulation studies indicate that the designed shikimic acid derivatives have good binding affinity and drug-like properties, and are stable in the active site of the SARS-CoV-2 main protease.
Hardha Balachandran, Kaviarasan Lakshmanan, Dipen Purohit et al.· Current Computer - Aided Dru...· 0 citations
The integration of TME-targeted and individualized therapeutic strategies may offer promising prospects toward achieving durable clinical outcomes in breast cancer treatment.
P. Shankar, Gowthamarajan Kuppusamy, Apsara Unni et al.· Current Cancer Therapy Revie...· 0 citations
Overall, compound B2 emerged as a promising PARP1 inhibitor with strong binding affinity, structural stability, and significant in vitro anticancer activity, warranting further optimization and preclinical investigation.
Hardha Balachandran, Subhajit Majumder, Gowramma Byran et al.· Current Medicinal Chemistry· 0 citations
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