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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

K. Rajapakshe

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Sep 2026

Abstract B083: Mutant KRAS cooperates with the hypoxic tumor microenvironment to drive immunosuppressive macrophages via a paracrine PGE2/GM-CSF axis

Hypoxia is known to drive an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC). However, the underlying immunosuppressive mechanisms remain unclear. Here, we hypothesized that hypoxia-induced factors secreted from tumor cells promoted immunosuppressive macrophages in PDAC. We tr...

Matthew T. Cribb, Ayeisha N. Colón-Ortiz, Sahar Fattani et al. · 0 citations
Open access Aug 2026

Targeting AXL Overcomes Adaptive Resistance to KRAS Inhibition in KRAS-Driven Cancer

By integrating adaptive response to KRAS inhibition with anti-tumor immunity, AXL represents a mechanistically actionable vulnerability whose inhibition deepens and prolongs responses to both allele-specific and pan-KRAS-targeted therapies.

F. Thege, A. Kramer, Norbert Kreisz et al. · 0 citations

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