Transforming Growth Factor-β1 Induces Concurrent Periostin and SLUG Expression in Normal Human Dermal Fibroblasts: Potential Implications for Extracellular Matrix Remodeling
Background: Transforming growth factor beta 1 (TGF-β1) is a master regulator of fibrogenesis and extracellular matrix (ECM) remodeling. Among molecules involved in profibrotic signaling, periostin (POSTN) and the Snail family transcriptional repressor 2 (SLUG, SNAI2) have emerged as potential regulators of tissue remod...