Author

K. Ristroph

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Open access Jul 2026

DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required

This study identifies anchoring strength as a critical, unconsidered parameter for in vivo performance when conjugating mAbs to LNPs for extrahepatic delivery.

Brian K. Wilson, Lucas D. Johnson, Jason Liu et al. · bioRxiv · 0 citations