ROS-Activated SHP-1 Signaling Underlies Artesunate-Mediated Inhibition of EMT and STAT3-Driven Prostate Cancer Progression.
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is a hallmark of prostate cancer (PC) progression. Here, we investigated the anticancer effects of artesunate (ART) and its underlying mechanisms in PC. ART selectively reduced the viability of PC cells with minimal toxicity toward no...