Author

K. Steiger

3 papers indexed here

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Sep 2026

Abstract A027: Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer

Loss of the Y chromosome (LOY) is a common somatic alteration in aging males and many cancer entities, yet its functional role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We sought to determine whether LOY is a recurrent, functionally consequential event in male PDAC and to define its impact on tu...

M. Dorsch, Felix E. G. Beaudry, A. Baginska et al. · Cancer Research · 0 citations

Open access Sep 2026

Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomyelitis.

Compartmentalized inflammation within the CNS is considered to drive progressive immunopathology in multiple sclerosis (MS) independently of relapses. Meningeal tertiary lymphoid structures (TLS) represent an immune niche associated with histological signs of immunopathology, including demyelination in the adjacent CNS...

Sofia Tyystjärvi, Diego Ruiz Navarro, Leni-Mihaela Kulisch et al. · Brain : a journal of neurolo... · 0 citations

Open access Aug 2026

A single-cell multi-omic atlas of the human pancreas reveals potential for cellular plasticity across development, health, and disease.

A single-cell multiomics atlas of the human pancreas is presented, profiling over four million cells and nuclei from 57 donors across fetal development, adult homeostasis, and type 2 diabetes.

E. Mereu, D. Balboa, J. Liebig et al. · Cell Metabolism · 1 citation