Author

K. Sukhova

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Open access Aug 2026

Emerging Haemagglutinin Mutations in Bovine-origin H5N1 Influenza Viruses from Humans and Cattle Retain Avian Receptor Binding with Increased Stability

The current H5N1 panzootic has seen an unprecedented host range expansion, including sustained circulation in US dairy cattle, detected in March 2024. By July 2026, infections had been reported on more than 1,150 dairy farms across 19 states. Although the outbreak initially centred in Texas, California has emerged as t...

Jia-Yun Yang, Tom Peacock, Kristel Paola Ramirez Valdez et al. · bioRxiv · 0 citations

Open access Jul 2026

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antivirals

A new paradigm for the evolutionary drivers of haemagglutinin is presented, where reduced sialic acid binding can serve as an advantage for escape from host barriers and antivirals.

K. Sukhova, Jia-Yun Yang, Antonio di Maio et al. · bioRxiv · 0 citations

Open access Jul 2026

Biomarkers of protection against controlled human SARS-CoV-2 Delta variant breakthrough infection

Susceptibility to SARS-CoV-2 breakthrough infection in those with hybrid immunity is strongly associated with low levels of pre-existing antibody, but the diversity of immune markers associated with protection implies that additional benefits may be conferred by multi-pronged immunity.

A. Singanayagam, H. Wagstaffe, L. J. Slater et al. · medRxiv · 0 citations