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Author

K. Tan

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Aug 2026

AcrPLMEvo: A Two-Stage Framework Integrating Evolutionary Profiles with Protein Language Models for Anti-CRISPR Prediction.

Anti-CRISPR (Acr) proteins are natural inhibitors of CRISPR-Cas systems and are important regulators for controllable genome-editing applications. However, their computational identification remains challenging because Acrs are sequence-diverse, weakly conserved, and supported by limited labeled data. Here, we present...

K. Tan, Wei-Di Sun, M. Fullwood et al. · 0 citations
Open access Jul 2026

Cross-phosphorylation of RR06 by the non-cognate kinase VncS activates the adhesin CbpA in Streptococcus pneumoniae

Determinants of pneumococcal adhesion to human alveolar epithelial cells are identified at both the serotype and genotype levels and a regulatory node is revealed that links two signaling systems to a single virulence output is revealed.

Si-Yin Tan, J. Zik, Y. Chun et al. · 0 citations

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