Author

K. Thakur

2 papers indexed here

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Open access Sep 2026

Saikosaponin A Induces Apoptosis in HCT116 Colorectal Cancer Cells via ROS-Mediated ER Stress and p38/JNK MAPK Pathway Activation: in Vitro and in Vivo Evidence

Colorectal cancer (CRC) is the third most prevalent cancer globally, with limited effective treatment options and significant chemotherapy resistance. Saikosaponin A (SSA), a triterpenoid saponin from Radix Bupleuri, exhibits anti-inflammatory and antitumor properties, but its mechanism of action in CRC remains und...

Xiu-Xiu Zhang, Jing-Ling Yang, Wang-Wei Zhang et al. · Food Science and Human Welln... · 0 citations

Aug 2026

Targeting the PLEC/TPM4 cytoskeletal axis: DT-13 inhibits colorectal cancer metastasis through direct binding to PLEC and inactivation of Akt/ERK signaling.

DT-13 exerts anti-metastatic effects in CRC by disrupting the PLEC/TPM4 cytoskeletal scaffold and suppressing the epithelial-mesenchymal transition process, highlighting the clinical potential of DT-13 as a safer therapeutic alternative for patients with metastatic CRC.

Jing-Yu Feng, Jing-Ling Yang, Rui Zhang et al. · Phytomedicine · 0 citations