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Author

K. Tyc

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Open access Aug 2026

Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism

Obesity increases circulating levels of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). Here, we identify adipocyte-expressed sphingosine kinase 2 (SPHK2), an enzyme that produces S1P, as a regulator of adipose tissue browning. Mice with adipocyte-specific deletion of Sphk2 were protected from West...

R. Brown, Cynthia Weigel, Yadu Vijayan et al. · 0 citations
Open access Aug 2026

A genome-wide in vivo screen reveals fitness pathways required for streptococcal infective endocarditis

Infective endocarditis (IE) is a life-threatening disease most often caused by blood-borne bacteria that infect previously damaged cardiac tissue. Despite the importance of this disease, the genetic basis for IE-associated fitness remains poorly defined. Here, we present the first genome-wide in vivo analysis of bacter...

Liang Bao, Jennifer Bradley, Vysakh Anandan et al. · 0 citations

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