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Author

K. Vignesh

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2 papers indexed here

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Open access Sep 2026

INDOLE-3-PROPIONIC ACID-MEDIATED NEPHROPROTECTION AGAINST GENTAMICIN INDUCED OXIDATIVE STRESS AND FERROPTOSIS IN HK-2 RENAL CELLS: AN IN VITRO STUDY

Objective: Gentamicin remains an effective aminoglycoside antibiotic; however, nephrotoxicity limits its therapeutic use. Proximal tubular epithelial injury induced by gentamicin involves oxidative stress, mitochondrial dysfunction, lipid peroxidation and ferroptosis. Indole-3-propionic acid (IPA), a gut microbiota-der...

Avinash Devaraneni, K. Vignesh, J. M. Joy et al. · 0 citations
Open access Sep 2026

IN VITRO EVALUATION OF HESPERIDIN AS A HEPATOPROTECTIVE AGENT AGAINST CYCLOPHOSPHAMIDE-INDUCED OXIDATIVE AND INFLAMMATORY INJURY

Objective: The objective of the study is to investigate the hepatoprotective effects of hesperidin against cyclophosphamide-induced oxidative stress and inflammatory injury in HepG2 cells, with particular emphasis on modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) antioxidan...

Gundeti Tharun Reddy, K. Vignesh, J. M. Joy et al. · 0 citations

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