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Author

K. Zarnack

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Open access Sep 2026

Programmed ribosomal frameshifting triggers translational stress to promote viral replication.

Programmed ribosomal frameshifting (PRF) is a conserved viral strategy for expressing polyproteins from compact genomes. Although PRF is traditionally viewed as a structural mechanism, here we show that it functions as a regulatory signal that rewires host translation in favor of viral replication. A minimal SARS-CoV-2...

Audrey Xavier, Melinda Kolling, Ashley M. Bourke et al. · 0 citations
Open access Aug 2026

Granule microenvironment regulates the dual functions of FMR1

It is shown that the condensation propensity of FMR1 containing granules regulates the two antagonistic functions, such that phase separation by FMR1-CTD creates the molecular microenvironment necessary for the repressive activity, whereas reduction in phase separation is associated with increased translation.

Vaishali Grewal, Frank Wippich, Danilo Lüdke et al. · 0 citations

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